TONSL

Across TCGA cell cohorts, TONSL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,901 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TONSL-associated GO terms across cancer lineages are Cell cycle DNA replication, DNA-templated DNA replication, and Positive regulation of DNA-directed DNA polymerase activity. Each is linked with TONSL in more than 18 cancer types. Because this analysis shows association rather than direction, both TONSL-to-partner and partner-to-TONSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle DNA replication grouped by TONSL-low versus TONSL-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TONSL→partner) and Y-score (partner→TONSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cell cycle DNA replication →	+0.150	+1.252	<.001	<.001	3	19
BONE	DNA-templated DNA replication →	+0.179	+2.727	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Positive regulation of DNA-directed DNA polymerase activity →	+0.203	+1.289	.001	<.001	3	19
PANCREAS	Nuclear DNA replication →	+0.144	+1.253	<.001	<.001	3	19
PANCREAS	Leading strand elongation →	+0.200	+1.412	<.001	<.001	3	19
BONE	DNA recombination →	+0.126	+2.624	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,901 associations by consensus.

Cell cycle DNA replication by TONSL expression — PANCREAS

Explore this box plot interactively →