TONSL

Across TCGA cell cohorts, TONSL mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TONSL-associated genes across cancer lineages are LRRC3C, TNP2, and ZFP90. Each is linked with TONSL in more than 1 cancer types. Because this analysis shows association rather than direction, both TONSL-to-partner and partner-to-TONSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by TONSL-low versus TONSL-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TONSL→partner) and Y-score (partner→TONSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LRRC3C →	+0.074	+3.807	.001	.003	3	2
BLOOD_Leukemia	TNP2 →	+0.031	+2.259	<.001	.003	3	2
BLOOD_Leukemia	ZFP90 →	+0.743	+2.489	.005	.007	3	2
LARGE_INTESTINE	C3orf20 →	+0.077	+3.464	.003	.004	3	2
LUNG_NSCLC_LUAD	TMEM114 →	+0.042	+3.040	<.001	.002	3	2
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

LRRC3C by TONSL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →