TONSL-AS1

Across TCGA pan-cancer cohorts, TONSL-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TONSL-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher TONSL-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TONSL-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

UVM, ACC, and KIRC are the cancer types where TONSL-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.541	0.865	<.001	113	view →
ACC	OS	Median	All	0.763	0.974	<.001	62	view →
KIRC	DFS	Tertile	IV	0.215	0.472	.004	52	view →
LGG	OS	Median	All	0.349	0.528	<.001	47	view →
SKCM	OS	Tertile	All	0.262	0.532	.002	31	view →
CESC	DFS	Median	All	0.767	0.873	.002	26	view →
HNSC	OS	Tertile	II,III,IV	0.507	0.320	.004	25	view →
UCS	DFS	Tertile	IV	0.250	0.885	.024	24	view →
THCA	OS	Median	All	0.963	1.000	.013	17	view →
UCEC	OS	Quartile	IV	0.805	0.292	.002	14	view →
PRAD	DFS	Quartile	All	0.881	0.953	.011	12	view →
KICH	OS	Tertile	III,IV	0.301	0.845	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TONSL-AS1–UVM (OS)

Open the UVM breakdown →