TOMM5

Across TCGA patient cohorts, TOMM5 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TOMM5-associated genes across cancer lineages are RNU2-14P, MIR378E, and MIR3612. Each is linked with TOMM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOMM5-to-partner and partner-to-TOMM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-14P grouped by TOMM5-low versus TOMM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOMM5→partner) and Y-score (partner→TOMM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU2-14P →	+0.798	+5.133	<.001	.008	3	2
UCEC	MIR378E →	+1.096	+6.453	<.001	.001	3	1
UCEC	MIR3612 →	+0.771	+5.186	<.001	.007	3	1
UCEC	RFC3P1 →	+0.336	+5.771	<.001	.003	3	1
COAD	RNU6-369P →	+0.411	+7.741	<.001	.009	3	1
COAD	RNU6-832P →	+0.394	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RNU2-14P by TOMM5 expression — UCEC

Explore this box plot interactively →