TOMM5

Across TCGA cell cohorts, TOMM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,807 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TOMM5-associated GO terms across cancer lineages are tRNA surveillance, Transcription elongation by RNA polymerase I, and DNA replication initiation. Each is linked with TOMM5 in more than 15 cancer types. Because this analysis shows association rather than direction, both TOMM5-to-partner and partner-to-TOMM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA surveillance grouped by TOMM5-low versus TOMM5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOMM5→partner) and Y-score (partner→TOMM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	tRNA surveillance →	+0.119	+0.743	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Transcription elongation by RNA polymerase I →	+0.130	+0.945	.005	.009	3	14
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.161	+0.793	<.001	.001	3	13
KIDNEY	tRNA 5'-leader removal →	+0.125	+0.880	.001	<.001	3	13
SOFT_TISSUE	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.130	+0.610	<.001	<.001	3	13
LUNG_NSCLC_LUSC	[2Fe-2S] cluster assembly →	+0.134	+0.905	<.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,807 associations by consensus.

tRNA surveillance by TOMM5 expression — SKIN

Explore this box plot interactively →