Q-omics provides the consensus-scored TOMM40P3 profile across patient tissues and cancer cell-line models. TOMM40P3 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, TOMM40P3 is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, TOMM40P3 RNA expression shows 5,795 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KICH, HNSC, and STAD as cancer lineages where TOMM40P3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TOMM40P3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TOMM40P3 survival associations across molecular data types. TOMM40P3 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TOMM40P3 RNA expression–survival associations across cancer types. High TOMM40P3 expression shows unfavorable associations in KICH, THCA, CHOL, ACC, COAD and PAAD. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .006). Together, the overview and detailed table identify KICH as the clearest survival context for TOMM40P3 RNA expression.
This table summarizes TOMM40P3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for TOMM40P3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TOMM40P3 shows higher tumor expression in HNSC, LUAD, COAD and LUSC. The HNSC box plot shows higher TOMM40P3 RNA expression in tumor versus normal tissue (log2 FC = +0.021, t-test p = .013).
This table shows molecular features associated with TOMM40P3 in patient tissues and cancer cell lines. In patient samples, TOMM40P3 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
