TOMM40

Across TCGA pan-cancer cohorts, TOMM40 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TOMM40’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TOMM40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOMM40 is over-expressed in tumor.

BLCA, COAD, and KIRP are the cancer types where TOMM40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOMM40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.328	<.001	11	view →
COAD	Female	All	+1.255	<.001	11	view →
KIRP	All	II,III,IV	+0.893	<.001	11	view →
KIRC	Female	All	+0.613	<.001	11	view →
STAD	Male	III,IV	+1.683	<.001	10	view →
HNSC	Male	IV	+1.175	<.001	10	view →
LIHC	Female	II,III,IV	+1.645	<.001	9	view →
LUAD	All	III,IV	+1.262	<.001	9	view →
LUSC	Male	III,IV	+2.087	<.001	8	view →
KICH	All	All	+0.470	<.001	7	view →
UCEC	All	III,IV	+1.681	<.001	6	view →
BRCA	All	III,IV	+0.953	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TOMM40–BLCA

Open the BLCA breakdown →