TOMM34

Across TCGA pan-cancer cohorts, TOMM34 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TOMM34 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TOMM34 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TOMM34 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and LSCC are the cancer types where TOMM34 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.884	.025	12	view →
UCEC	DFS	Median	III,IV	0.904	0.295	.037	8	view →
LSCC	DFS	Tertile	II,III,IV	0.316	1.000	.006	6	view →
CCRCC	OS	Tertile	II,III,IV	0.658	0.898	.030	5	view →
HNSC	OS	Tertile	II,III,IV	0.778	0.918	.017	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TOMM34–COAD (DFS)

Open the COAD breakdown →