TOMM20

Across TCGA pan-cancer cohorts, TOMM20 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TOMM20 data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TOMM20 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TOMM20 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, ACC, and CESC are the cancer types where TOMM20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.740	0.527	<.001	123	view →
ACC	DFS	Median	All	0.153	0.674	<.001	90	view →
CESC	DFS	Median	All	0.414	0.651	<.001	86	view →
KIRP	DFS	Quartile	All	0.801	0.951	.001	66	view →
PAAD	OS	Median	All	0.299	0.487	.005	43	view →
LGG	DFS	Median	All	0.469	0.263	<.001	38	view →
LIHC	OS	Tertile	All	0.687	0.891	<.001	37	view →
SCLC	DFS	Quartile	All	0.373	0.661	.010	31	view →
COAD	OS	Median	All	0.950	0.787	<.001	30	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	27	view →
HNSC	OS	Quartile	All	0.290	0.703	.003	22	view →
DLBC	OS	Median	IV	0.417	1.000	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TOMM20–KIRC (DFS)

Open the KIRC breakdown →