TOM1L1

Across TCGA pan-cancer cohorts, TOM1L1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TOM1L1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TOM1L1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TOM1L1 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where TOM1L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOM1L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.669	<.001	12	view →
CCRCC	All	IV	−0.522	<.001	12	view →
LSCC	Female	All	−0.415	<.001	9	view →
PDAC	Female	All	−0.971	<.001	8	view →
LUAD	Female	All	+0.272	<.001	4	view →
COAD	Female	II,III,IV	+0.185	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TOM1L1–HNSC

Open the HNSC breakdown →