TOM1L1

Across TCGA patient cohorts, TOM1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOM1L1-associated genes across cancer lineages are GTF2F2P2, LYPLA1P1, and COX15. Each is linked with TOM1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOM1L1-to-partner and partner-to-TOM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF2F2P2 grouped by TOM1L1-low versus TOM1L1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1L1→partner) and Y-score (partner→TOM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GTF2F2P2 →	+0.100	+5.481	<.001	.005	3	2
COAD	LYPLA1P1 →	+0.211	+4.824	<.001	.002	3	2
UCEC	COX15 →	+0.458	+2.502	.001	.002	3	2
UCEC	SKA1 →	+0.669	+3.191	.001	.009	3	2
UCEC	SEC13 →	+0.403	+2.848	.001	.001	3	2
UCEC	SAP30 →	+0.598	+2.021	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,059 associations by consensus.

GTF2F2P2 by TOM1L1 expression — LUAD

Explore this box plot interactively →