TOM1L1

Across TCGA patient cohorts, TOM1L1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOM1L1-associated genes across cancer lineages are PCNA, JNK2, and Myosin-IIa_pS1943. Each is linked with TOM1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOM1L1-to-partner and partner-to-TOM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TOM1L1-low versus TOM1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1L1→partner) and Y-score (partner→TOM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.227	+2.807	.016	.003	3	3
UCEC	JNK2 →	+0.258	+2.807	.002	.003	3	1
UCEC	Myosin-IIa_pS1943 →	+0.192	+2.128	.033	.010	3	1
UCEC	Annexin-1 →	+0.822	+3.604	<.001	.001	3	1
UCEC	TFRC →	+0.532	+2.999	.021	.035	3	1
UCEC	VHL →	-0.753	-2.459	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PCNA by TOM1L1 expression — UCEC

Explore this box plot interactively →