TOLLIP-AS1

Across TCGA pan-cancer cohorts, TOLLIP-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TOLLIP-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TOLLIP-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TOLLIP-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BRCA show a favorable association.

KIRP, BRCA, and CHOL are the cancer types where TOLLIP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.844	0.530	<.001	93	view →
BRCA	OS	Tertile	All	0.952	0.895	.004	40	view →
CHOL	OS	Tertile	All	0.925	0.389	.002	39	view →
CESC	OS	Quartile	II,III,IV	0.927	0.696	.004	38	view →
STAD	DFS	Median	IV	0.168	0.600	.004	33	view →
ACC	DFS	Tertile	All	0.358	0.894	.003	29	view →
PAAD	DFS	Quartile	All	0.361	0.153	.013	27	view →
LUAD	OS	Tertile	III,IV	0.845	0.457	<.001	27	view →
LUSC	OS	Tertile	II,III,IV	0.835	0.691	.010	17	view →
DLBC	DFS	Median	All	0.604	0.931	.005	15	view →
LGG	OS	Tertile	All	0.645	0.424	.005	14	view →
COAD	DFS	Quartile	II,III,IV	0.561	0.823	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TOLLIP-AS1–KIRP (OS)

Open the KIRP breakdown →