TOB2P1

Across TCGA pan-cancer cohorts, TOB2P1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TOB2P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TOB2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOB2P1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where TOB2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOB2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.092	<.001	11	view →
THCA	Male	III,IV	−0.917	<.001	11	view →
HNSC	Male	All	+0.767	<.001	11	view →
LIHC	Male	All	+1.216	<.001	9	view →
BLCA	All	All	+1.119	<.001	9	view →
KIRP	All	IV	+1.572	.032	6	view →
BRCA	All	All	+0.385	<.001	6	view →
LUSC	Male	All	+0.709	<.001	5	view →
LUAD	Male	All	+0.578	<.001	5	view →
STAD	All	II,III,IV	+0.601	.001	4	view →
CHOL	All	All	+0.808	.028	2	view →
UCEC	All	All	+0.467	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TOB2P1–KIRC

Open the KIRC breakdown →