Across TCGA pan-cancer cohorts, TOB2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TOB2 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TOB2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOB2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC and UCEC are the cancer types where TOB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.268	0.850	.002	60	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.424	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TOB2 tumor-vs-normal RNA expression · all TOB2 data types