Across TCGA patient cohorts, TOB2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,396 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TOB2-associated proteins across cancer lineages are HSP90B1, TOB2_S222, and TTLL12. Each is linked with TOB2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TOB2-to-partner and partner-to-TOB2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB2→partner) and Y-score (partner→TOB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSP90B1 →	-0.390	-0.551	<.001	<.001	3	6
BRCA	TOB2_S222 →	+0.583	+0.619	<.001	<.001	3	5
LSCC	TTLL12 →	+0.450	+0.381	<.001	.001	3	4
GBM	NCKAP1 →	+0.211	+0.438	<.001	<.001	3	4
CCRCC	PTPN1 →	-0.393	-0.620	<.001	<.001	3	4
GBM	CTNNA1 →	+0.347	+0.461	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,396 associations by consensus.

Exploration

TOB2 survival (RNA) · tumor vs normal (RNA) · all TOB2 data types