Across TCGA patient cohorts, TOB2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOB2-associated genes across cancer lineages are EGFR_pY1068, ERK2, and GAPDH. Each is linked with TOB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOB2-to-partner and partner-to-TOB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB2→partner) and Y-score (partner→TOB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.319	-3.321	.004	.010	3	1
UCEC	ERK2 →	+0.191	+2.000	.027	.032	3	1
UCEC	GAPDH →	+0.584	+3.000	.015	.036	3	1
UCEC	ACC1 →	+0.322	+3.013	.049	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.459	+2.700	.045	.006	3	1
UCEC	Ku80 →	+0.251	+2.713	.018	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

TOB2 survival (RNA) · tumor vs normal (RNA) · all TOB2 data types