Across TCGA cell cohorts, TOB2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOB2-associated genes across cancer lineages are CNBD1, OR4N4, and OR2B3. Each is linked with TOB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOB2-to-partner and partner-to-TOB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB2→partner) and Y-score (partner→TOB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNBD1 →	+0.576	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR4N4 →	+0.036	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR2B3 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	POTEB2 →	+0.012	+5.415	<.001	.004	3	1
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ODF4 →	+0.057	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

TOB2 survival (RNA) · tumor vs normal (RNA) · all TOB2 data types