TOB1

Across TCGA patient cohorts, TOB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,893 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TOB1-associated proteins across cancer lineages are TOB1_S205, THEMIS2, and ICAM1. Each is linked with TOB1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TOB1-to-partner and partner-to-TOB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOB1 versus TOB1_S205 in BRCA, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB1→partner) and Y-score (partner→TOB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TOB1_S205 →	+1.093	+1.451	<.001	<.001	3	7
LSCC	THEMIS2 →	-0.450	-0.475	<.001	<.001	3	4
BRCA	ICAM1 →	-0.643	-1.079	<.001	<.001	3	4
BRCA	CD163 →	-0.443	-1.049	.002	.002	2	5
BRCA	CEP170 →	-0.306	-0.878	<.001	<.001	3	4
HNSC	PSMB6 →	+0.399	+0.717	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,893 associations by consensus.

TOB1 vs TOB1_S205 — BRCA

Explore this scatter interactively →