TOB1

Across TCGA patient cohorts, TOB1 mutation is significantly associated with the RNA expression of many other genes, with 505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOB1-associated genes across cancer lineages are RN7SL654P, MIR887, and RNU6-959P. Each is linked with TOB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOB1-to-partner and partner-to-TOB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL654P grouped by TOB1-low versus TOB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB1→partner) and Y-score (partner→TOB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL654P →	+0.155	+3.235	<.001	.001	3	3
BLCA	MIR887 →	+0.276	+4.899	<.001	.005	3	2
UCEC	RNU6-959P →	+0.227	+3.027	.001	.007	3	2
UCEC	GPR75-ASB3 →	+0.065	+3.965	.006	<.001	3	1
UCEC	RPS28P1 →	+0.111	+3.027	<.001	.007	3	1
UCEC	BNIP3P4 →	+0.053	+3.025	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 505 associations by consensus.

RN7SL654P by TOB1 expression — UCEC

Explore this box plot interactively →