TOB1

Across TCGA patient cohorts, TOB1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOB1-associated genes across cancer lineages are MEK1, mTOR_pS2448, and Notch1. Each is linked with TOB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOB1-to-partner and partner-to-TOB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TOB1-low versus TOB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB1→partner) and Y-score (partner→TOB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.571	+3.584	.001	.002	3	1
UCEC	mTOR_pS2448 →	-0.145	-2.980	.044	.036	3	1
UCEC	Notch1 →	+0.180	+2.459	.008	.020	3	1
UCEC	p62 Lck ligand →	+0.525	+2.179	<.001	.034	3	1
UCEC	PCNA →	+0.255	+2.999	.014	.035	3	1
UCEC	Rictor_pT1135 →	-0.109	-2.459	.027	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MEK1 by TOB1 expression — UCEC

Explore this box plot interactively →