TOB1

Across TCGA cell cohorts, TOB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,824 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TOB1-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, and Regulation of nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with TOB1 in more than 16 cancer types. Because this analysis shows association rather than direction, both TOB1-to-partner and partner-to-TOB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay grouped by TOB1-low versus TOB1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOB1→partner) and Y-score (partner→TOB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.199	+1.923	<.001	<.001	3	17
URINARY_TRACT	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.158	+1.531	<.001	<.001	3	17
URINARY_TRACT	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.131	+1.216	<.001	.005	2	15
OESOPHAGUS	Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.126	+1.478	.001	.001	3	12
PANCREAS	Pressure natriuresis →	+1.292	+1.244	<.001	<.001	3	11
STOMACH	Phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.114	+1.447	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,824 associations by consensus.

Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay by TOB1 expression — STOMACH

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