TOB1-AS1

Across TCGA pan-cancer cohorts, TOB1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TOB1-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher TOB1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TOB1-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and LGG show a favorable association.

MESO, LGG, and UCEC are the cancer types where TOB1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.703	0.430	<.001	41	view →
LGG	DFS	Tertile	All	0.902	0.765	<.001	34	view →
UCEC	DFS	Quartile	All	0.816	0.923	.001	28	view →
SKCM	DFS	Quartile	All	0.680	0.539	<.001	27	view →
UVM	OS	Median	II,III,IV	0.747	0.941	.001	23	view →
BRCA	OS	Tertile	IV	0.981	0.402	.004	20	view →
LAML	DFS	Tertile	All	0.239	0.483	.018	18	view →
PRAD	DFS	Median	All	0.674	0.874	<.001	18	view →
THYM	OS	Tertile	All	1.000	0.764	.012	16	view →
OV	DFS	Quartile	IV	0.531	0.299	.026	10	view →
PAAD	OS	Quartile	All	0.616	0.260	.011	9	view →
READ	DFS	Median	All	0.714	0.416	.025	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TOB1-AS1–MESO (OS)

Open the MESO breakdown →