TNXB

Across TCGA pan-cancer cohorts, TNXB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TNXB data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TNXB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TNXB expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where TNXB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.868	0.557	<.001	93	view →
CCRCC	DFS	Median	IV	0.220	0.781	.017	22	view →
LUAD	DFS	Median	II,III,IV	0.665	0.990	.002	11	view →
OV	DFS	Quartile	All	0.654	1.000	.049	4	view →
LSCC	DFS	Median	II,III,IV	0.870	0.963	.047	2	view →
HNSC	OS	Tertile	II,III,IV	0.944	1.000	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TNXB–PDAC (DFS)

Open the PDAC breakdown →