TNXB

Across TCGA patient cohorts, TNXB mutation is significantly associated with the RNA expression of many other genes, with 7,796 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNXB-associated genes across cancer lineages are CDK16, C6orf136, and RFC2. Each is linked with TNXB in more than 4 cancer types. Because this analysis shows association rather than direction, both TNXB-to-partner and partner-to-TNXB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK16 grouped by TNXB-low versus TNXB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNXB→partner) and Y-score (partner→TNXB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDK16 →	+0.511	+2.711	<.001	.003	3	5
BRCA	C6orf136 →	+0.429	+3.812	<.001	<.001	3	5
BRCA	RFC2 →	+0.418	+2.705	.005	.003	3	5
UCEC	USP39 →	+0.242	+1.720	<.001	<.001	3	5
STAD	FAM136A →	+0.331	+2.297	.008	<.001	3	5
UCEC	CDC7 →	+0.518	+1.868	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,796 associations by consensus.

CDK16 by TNXB expression — BRCA

Explore this box plot interactively →