TNXB

Across TCGA cell cohorts, TNXB mutation is significantly associated with the RNA expression of many other genes, with 1,554 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNXB-associated genes across cancer lineages are C19orf48, UBE3A, and CTNNAL1. Each is linked with TNXB in more than 3 cancer types. Because this analysis shows association rather than direction, both TNXB-to-partner and partner-to-TNXB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C19orf48 grouped by TNXB-low versus TNXB-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNXB→partner) and Y-score (partner→TNXB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C19orf48 →	+0.423	+1.807	.008	.007	3	4
BLOOD_Leukemia	UBE3A →	+0.474	+3.714	.001	<.001	3	3
BLOOD_Leukemia	CTNNAL1 →	+0.648	+3.321	.007	.005	3	3
BLOOD_Leukemia	GZF1 →	+0.403	+2.148	.003	.009	3	3
LARGE_INTESTINE	PRPSAP2 →	+0.520	+1.545	.001	.004	3	3
BLOOD_Leukemia	INA →	+1.177	+3.574	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,554 associations by consensus.

C19orf48 by TNXB expression — LUNG_SCLC

Explore this box plot interactively →