TNS4

Across TCGA pan-cancer cohorts, TNS4 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TNS4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNS4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TNS4 is over-expressed in tumor.

HNSC, PDAC, and COAD are the cancer types where TNS4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNS4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.924	<.001	11	view →
PDAC	All	III,IV	+1.693	<.001	9	view →
COAD	All	All	+0.863	<.001	9	view →
LSCC	Female	II,III,IV	+1.271	<.001	8	view →
CCRCC	All	All	+0.829	.002	4	view →
LUAD	All	All	+0.353	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TNS4–HNSC

Open the HNSC breakdown →