TNS4

Across TCGA patient cohorts, TNS4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNS4-associated genes across cancer lineages are A-Raf_pS299, Caspase-7-cleavedD198, and FoxM1. Each is linked with TNS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNS4-to-partner and partner-to-TNS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TNS4-low versus TNS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS4→partner) and Y-score (partner→TNS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.120	-2.700	.008	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.678	+2.827	.002	.001	3	2
SKCM	FoxM1 →	+0.156	+1.362	.031	.035	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.604	+2.459	.001	.017	3	1
SKCM	IRS1 →	+0.149	+2.087	.005	.004	3	1
SKCM	p27_pT157 →	+0.148	+2.661	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

A-Raf_pS299 by TNS4 expression — UCEC

Explore this box plot interactively →