TNS1

Across TCGA pan-cancer cohorts, TNS1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TNS1 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TNS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TNS1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

HNSC, STAD, and BRCA are the cancer types where TNS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.223	0.745	<.001	48	view →
STAD	OS	Median	II,III,IV	0.918	0.396	.004	24	view →
BRCA	OS	Median	All	0.583	0.924	<.001	23	view →
LUSC	DFS	Median	All	0.149	0.718	<.001	12	view →
UCEC	DFS	Median	All	0.750	0.632	.016	12	view →
READ	DFS	Median	III,IV	1.000	0.302	.030	10	view →
SARC	DFS	Median	All	0.126	0.595	.004	6	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TNS1–HNSC (OS)

Open the HNSC breakdown →