TNS1

Across TCGA pan-cancer cohorts, TNS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNS1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TNS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TNS1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where TNS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.845	0.605	.007	24	view →
GBM	DFS	Quartile	All	0.547	0.926	.001	22	view →
CCRCC	DFS	Tertile	III,IV	0.715	0.317	.003	12	view →
LUAD	DFS	Median	II,III,IV	0.711	0.947	.005	11	view →
LSCC	DFS	Quartile	II,III,IV	0.843	1.000	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TNS1–PDAC (DFS)

Open the PDAC breakdown →