TNS1

Across TCGA patient cohorts, TNS1 mutation is significantly associated with the RNA expression of many other genes, with 6,390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNS1-associated genes across cancer lineages are SGO1, KIF11, and ACTR6. Each is linked with TNS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TNS1-to-partner and partner-to-TNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGO1 grouped by TNS1-low versus TNS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS1→partner) and Y-score (partner→TNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SGO1 →	+0.426	+1.656	.002	<.001	3	6
UCEC	KIF11 →	+0.501	+1.483	.002	<.001	3	6
LUAD	ACTR6 →	+0.634	+2.596	<.001	.006	2	6
UCEC	LRRC58 →	+0.337	+1.451	.007	<.001	3	5
UCEC	SGO2 →	+0.388	+1.592	.005	.001	3	5
UCEC	CENPN →	+0.528	+1.606	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,390 associations by consensus.

SGO1 by TNS1 expression — UCEC

Explore this box plot interactively →