TNS1

Across TCGA patient cohorts, TNS1 mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNS1-associated genes across cancer lineages are Cyclin-B1, PCNA, and YAP_pS127. Each is linked with TNS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNS1-to-partner and partner-to-TNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TNS1-low versus TNS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNS1→partner) and Y-score (partner→TNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.612	+1.678	<.001	<.001	3	4
STAD	PCNA →	+0.271	+3.169	.016	.017	3	3
STAD	YAP_pS127 →	-0.395	-2.807	.001	.003	3	3
STAD	ASNS →	+0.366	+3.321	.036	.008	3	3
COAD	Caspase-7-cleavedD198 →	+1.136	+1.745	<.001	.004	3	3
STAD	4E-BP1 →	+0.439	+2.115	<.001	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Cyclin-B1 by TNS1 expression — UCEC

Explore this box plot interactively →