TNRC6C

Across TCGA patient cohorts, TNRC6C mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNRC6C-associated genes across cancer lineages are C-Raf, ACC1, and ASNS. Each is linked with TNRC6C in more than 3 cancer types. Because this analysis shows association rather than direction, both TNRC6C-to-partner and partner-to-TNRC6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by TNRC6C-low versus TNRC6C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6C→partner) and Y-score (partner→TNRC6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.145	+1.321	<.001	.027	3	4
UCEC	ACC1 →	+0.280	+1.515	.009	.015	3	3
UCEC	ASNS →	+0.346	+1.584	.001	.008	3	3
UCEC	Caspase-7-cleavedD198 →	+0.437	+1.267	.012	.026	3	3
SKCM	p53 →	+0.240	+2.700	<.001	.005	3	2
SKCM	PRDX1 →	+0.231	+2.000	.035	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

C-Raf by TNRC6C expression — UCEC

Explore this box plot interactively →