TNRC6C

Across TCGA cell cohorts, TNRC6C mutation is significantly associated with the mutation status of many other genes, with 5,345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNRC6C-associated genes across cancer lineages are COL7A1, DOCK10, and BSN. Each is linked with TNRC6C in more than 6 cancer types. Because this analysis shows association rather than direction, both TNRC6C-to-partner and partner-to-TNRC6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL7A1 grouped by TNRC6C-low versus TNRC6C-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNRC6C→partner) and Y-score (partner→TNRC6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	COL7A1 →	+2.906	+2.554	.006	.006	1	7
BLOOD_Lymphoma	DOCK10 →	+2.969	+3.337	.009	.009	1	7
OVARY	BSN →	+4.105	+5.318	<.001	<.001	1	7
BLOOD_Lymphoma	LAMA5 →	+2.591	+4.509	<.001	<.001	1	7
OVARY	ZFP64 →	+4.467	+3.240	.004	.004	1	6
UPPER_AERODIGESTIVE_TRACT	FLNB →	+3.321	+3.321	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,345 associations by consensus.

COL7A1 by TNRC6C expression — CNS

Explore this box plot interactively →