TNPO3

Across TCGA pan-cancer cohorts, TNPO3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNPO3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TNPO3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNPO3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where TNPO3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.708	0.898	.006	49	view →
LUAD	DFS	Median	All	0.461	0.747	.004	15	view →
UCEC	DFS	Quartile	All	0.779	0.957	.038	8	view →
LSCC	OS	Quartile	II,III,IV	0.933	0.516	.005	7	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TNPO3–CCRCC (DFS)

Open the CCRCC breakdown →