TNPO3

Across TCGA patient cohorts, TNPO3 mutation is significantly associated with the RNA expression of many other genes, with 5,152 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNPO3-associated genes across cancer lineages are WDHD1, NDC80, and SNW1. Each is linked with TNPO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TNPO3-to-partner and partner-to-TNPO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDHD1 grouped by TNPO3-low versus TNPO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO3→partner) and Y-score (partner→TNPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDHD1 →	+0.617	+2.895	<.001	<.001	3	4
UCEC	NDC80 →	+0.512	+1.745	.003	.004	3	4
LUSC	SNW1 →	+0.402	+3.632	.001	.001	3	3
LUSC	ALKBH8 →	+0.436	+3.339	.003	.005	3	3
UCEC	ENTR1 →	+0.514	+2.082	<.001	<.001	3	3
UCEC	EIF1AD →	+0.359	+2.093	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,152 associations by consensus.

WDHD1 by TNPO3 expression — UCEC

Explore this box plot interactively →