TNPO3

Across TCGA patient cohorts, TNPO3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNPO3-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and C-Raf. Each is linked with TNPO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNPO3-to-partner and partner-to-TNPO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TNPO3-low versus TNPO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO3→partner) and Y-score (partner→TNPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.548	+1.662	.001	.009	3	3
UCEC	c-Met_pY1235 →	+0.069	+1.726	.001	.001	3	3
UCEC	C-Raf →	+0.219	+2.099	<.001	<.001	3	2
UCEC	ACC1 →	+0.359	+1.920	<.001	.008	3	2
UCEC	Heregulin →	-0.125	-1.664	<.001	.019	3	2
UCEC	MEK1 →	+0.524	+2.369	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Caspase-7-cleavedD198 by TNPO3 expression — UCEC

Explore this box plot interactively →