TNPO3

Across TCGA cell cohorts, TNPO3 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNPO3-associated genes across cancer lineages are DCLK3, GZMK, and BTBD16. Each is linked with TNPO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNPO3-to-partner and partner-to-TNPO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCLK3 grouped by TNPO3-low versus TNPO3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO3→partner) and Y-score (partner→TNPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCLK3 →	+0.307	+3.769	<.001	.008	3	2
BLOOD_Leukemia	GZMK →	+0.484	+4.037	.001	.004	3	1
BLOOD_Leukemia	BTBD16 →	+0.113	+3.959	<.001	.005	3	1
BLOOD_Leukemia	CALHM4 →	+0.030	+4.269	<.001	.002	3	1
BLOOD_Leukemia	DIRAS2 →	+0.099	+4.087	<.001	.009	3	1
BLOOD_Leukemia	C16orf92 →	+0.213	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

DCLK3 by TNPO3 expression — BLOOD_Leukemia

Explore this box plot interactively →