TNPO2

Across TCGA patient cohorts, TNPO2 mutation is significantly associated with the RNA expression of many other genes, with 3,852 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNPO2-associated genes across cancer lineages are ACBD5, SLC17A5, and KNL1. Each is linked with TNPO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNPO2-to-partner and partner-to-TNPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by TNPO2-low versus TNPO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO2→partner) and Y-score (partner→TNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACBD5 →	+0.467	+1.874	<.001	<.001	3	3
UCEC	SLC17A5 →	+0.541	+1.917	<.001	<.001	3	3
UCEC	KNL1 →	+0.534	+2.329	<.001	<.001	3	3
UCEC	NFIC →	+0.435	+2.113	.001	<.001	3	3
UCEC	DYNLT3P2 →	+0.217	+1.343	<.001	.005	3	3
UCEC	RNU6-1149P →	+0.170	+1.613	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,852 associations by consensus.

ACBD5 by TNPO2 expression — UCEC

Explore this box plot interactively →