TNPO2

Across TCGA cell cohorts, TNPO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,626 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNPO2-associated GO terms across cancer lineages are Mitotic chromosome condensation, Positive regulation of T-helper 17 cell lineage commitment, and Chromosome condensation. Each is linked with TNPO2 in more than 18 cancer types. Because this analysis shows association rather than direction, both TNPO2-to-partner and partner-to-TNPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic chromosome condensation grouped by TNPO2-low versus TNPO2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO2→partner) and Y-score (partner→TNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Mitotic chromosome condensation →	+0.180	+0.974	<.001	.001	3	19
LUNG_NSCLC_LUSC	Positive regulation of T-helper 17 cell lineage commitment →	+0.199	+0.861	.002	.004	3	19
LUNG_SCLC	Chromosome condensation →	+0.194	+0.962	<.001	<.001	3	18
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.140	+0.666	.001	.001	3	18
LUNG_NSCLC_LUSC	DNA-templated transcription initiation →	+0.088	+1.428	<.001	<.001	3	18
LUNG_SCLC	Centrosome cycle →	+0.078	+0.726	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,626 associations by consensus.

Mitotic chromosome condensation by TNPO2 expression — BREAST

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