TNPO2

Across TCGA cell cohorts, TNPO2 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNPO2-associated genes across cancer lineages are SFT2D3, CSN3, and UBQLN3. Each is linked with TNPO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNPO2-to-partner and partner-to-TNPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFT2D3 grouped by TNPO2-low versus TNPO2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNPO2→partner) and Y-score (partner→TNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SFT2D3 →	+0.460	+4.095	<.001	.009	3	2
LUNG_SCLC	CSN3 →	+0.282	+4.269	<.001	.005	3	1
LUNG_SCLC	UBQLN3 →	+0.041	+4.044	<.001	.009	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.023	+3.867	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

SFT2D3 by TNPO2 expression — SKIN

Explore this box plot interactively →