TNPO1

Across TCGA pan-cancer cohorts, TNPO1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TNPO1 data layer compared with 30 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TNPO1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNPO1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UVM, UCEC, and PAAD are the cancer types where TNPO1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.032	0.762	<.001	30	view →
UCEC	DFS	Median	All	0.927	0.613	.009	22	view →
PAAD	OS	Median	All	0.131	0.613	.001	15	view →
TGCT	DFS	Median	All	0.172	0.801	.033	6	view →
BLCA	OS	Median	IV	0.243	0.602	.027	6	view →
ESCA	OS	Median	All	0.022	0.681	<.001	6	view →
SKCM	DFS	Median	All	0.783	0.187	.002	5	view →
BRCA	OS	Median	II,III,IV	0.592	0.912	.019	3	view →
LUAD	OS	Median	II,III,IV	0.237	0.709	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TNPO1–UVM (DFS)

Open the UVM breakdown →