TNPO1

Across TCGA pan-cancer cohorts, TNPO1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TNPO1 data layer compared with 30 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TNPO1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNPO1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where TNPO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.615	0.870	.001	57	view →
LUAD	OS	Median	All	1.000	0.893	.005	28	view →
UCEC	DFS	Quartile	II,III,IV	0.546	1.000	.031	6	view →
GBM	DFS	Tertile	All	0.261	0.561	.015	4	view →
HNSC	OS	Median	III,IV	0.787	0.584	.023	4	view →
PDAC	DFS	Quartile	All	0.691	0.860	.043	1	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TNPO1–CCRCC (DFS)

Open the CCRCC breakdown →