TNNT3

Across TCGA patient cohorts, TNNT3 mutation is significantly associated with the RNA expression of many other genes, with 1,692 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNT3-associated genes across cancer lineages are CENPU, GUF1, and NTAN1. Each is linked with TNNT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNT3-to-partner and partner-to-TNNT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by TNNT3-low versus TNNT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNT3→partner) and Y-score (partner→TNNT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.736	+2.354	<.001	<.001	3	2
UCEC	GUF1 →	+0.438	+2.931	<.001	<.001	3	2
UCEC	NTAN1 →	+0.452	+2.732	<.001	.003	3	2
UCEC	DONSON →	+0.584	+2.839	<.001	.001	3	2
UCEC	KIAA1841 →	+0.525	+3.040	<.001	<.001	3	2
UCEC	E2F7 →	+0.616	+3.332	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,692 associations by consensus.

CENPU by TNNT3 expression — UCEC

Explore this box plot interactively →