TNNI3K

Across TCGA patient cohorts, TNNI3K mutation is significantly associated with the RNA expression of many other genes, with 1,881 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI3K-associated genes across cancer lineages are MIR6803, RNA5SP420, and CDK4P1. Each is linked with TNNI3K in more than 3 cancer types. Because this analysis shows association rather than direction, both TNNI3K-to-partner and partner-to-TNNI3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by TNNI3K-low versus TNNI3K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI3K→partner) and Y-score (partner→TNNI3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.186	+4.893	<.001	<.001	3	4
UCEC	RNA5SP420 →	+0.444	+1.967	.001	.005	3	3
READ	CDK4P1 →	+0.161	+5.421	<.001	.005	3	2
READ	RAB11AP1 →	+0.354	+5.039	<.001	.008	3	2
BLCA	RN7SKP85 →	+0.152	+5.177	.001	.007	3	2
LUAD	MTND1P19 →	+0.126	+4.912	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,881 associations by consensus.

MIR6803 by TNNI3K expression — UCEC

Explore this box plot interactively →