TNNI3K

Across TCGA patient cohorts, TNNI3K mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI3K-associated genes across cancer lineages are Shc_pY317, 4E-BP1, and VHL. Each is linked with TNNI3K in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNI3K-to-partner and partner-to-TNNI3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TNNI3K-low versus TNNI3K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI3K→partner) and Y-score (partner→TNNI3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.148	-2.999	.015	.035	3	2
UCEC	4E-BP1 →	+0.306	+2.199	.005	.033	3	2
LUSC	VHL →	+1.087	+2.816	.021	.036	3	1
SKCM	Src →	-0.383	-3.169	.002	.019	3	1
UCEC	EGFR →	-0.162	-2.973	.012	.035	3	1
UCEC	eIF4E →	+0.176	+2.415	.038	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Shc_pY317 by TNNI3K expression — UCEC

Explore this box plot interactively →