TNNI2

Across TCGA pan-cancer cohorts, TNNI2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TNNI2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TNNI2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNNI2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where TNNI2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.712	0.955	.011	13	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	2	view →
LUAD	DFS	Median	All	0.898	1.000	.014	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TNNI2–LSCC (OS)

Open the LSCC breakdown →