TNNI2

Across TCGA patient cohorts, TNNI2 mutation is significantly associated with the RNA expression of many other genes, with 570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI2-associated genes across cancer lineages are RNU6-939P, RNU6-1020P, and HSPD1P18. Each is linked with TNNI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TNNI2-to-partner and partner-to-TNNI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-939P grouped by TNNI2-low versus TNNI2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI2→partner) and Y-score (partner→TNNI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-939P →	+0.267	+3.508	<.001	.006	3	3
LIHC	RNU6-1020P →	+0.308	+5.008	<.001	.004	3	2
LIHC	HSPD1P18 →	+0.126	+4.647	<.001	.007	3	2
SKCM	PRY →	+0.223	+3.023	<.001	.009	3	2
LIHC	HSPD1P13 →	+0.023	+4.758	<.001	.006	3	2
LUSC	MIR557 →	+0.692	+4.438	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 570 associations by consensus.

RNU6-939P by TNNI2 expression — SKCM

Explore this box plot interactively →