TNNI1

Across TCGA patient cohorts, TNNI1 mutation is significantly associated with the RNA expression of many other genes, with 2,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI1-associated genes across cancer lineages are IGHD2-15, OSTCP6, and SNRPEP7. Each is linked with TNNI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNI1-to-partner and partner-to-TNNI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-15 grouped by TNNI1-low versus TNNI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI1→partner) and Y-score (partner→TNNI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD2-15 →	+1.159	+1.824	.003	.006	3	2
UCEC	OSTCP6 →	+0.237	+1.996	.006	.005	3	2
SKCM	SNRPEP7 →	+0.236	+3.126	<.001	.007	3	2
UCEC	RNU6-1213P →	+0.174	+3.374	<.001	.003	3	2
SKCM	C2orf69P4 →	+0.029	+4.671	<.001	.004	3	2
SKCM	MEMO1P3 →	+0.091	+3.877	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,084 associations by consensus.

IGHD2-15 by TNNI1 expression — UCEC

Explore this box plot interactively →