TNNI1

Across TCGA patient cohorts, TNNI1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNNI1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR. Each is linked with TNNI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNNI1-to-partner and partner-to-TNNI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TNNI1-low versus TNNI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNNI1→partner) and Y-score (partner→TNNI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-2.401	.002	.003	3	1
UCEC	eEF2 →	+0.344	+2.321	.016	.034	3	1
UCEC	EGFR →	-0.180	-2.459	.005	.019	3	1
UCEC	eIF4G →	+0.283	+3.321	.023	.010	3	1
UCEC	ACC_pS79 →	+0.348	+1.906	.012	.016	3	1
UCEC	GAPDH →	+0.449	+2.459	.037	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

14-3-3_beta by TNNI1 expression — UCEC

Explore this box plot interactively →